alpha 2 Macroglobulin anticorps

N° du produit ABIN5541044

Cet anticorps Souris Monoclonal détecte spécifiquement alpha 2 Macroglobulin dans EIA et RIA. Il présente une réactivité envers Humain.

Aperçu rapide pour alpha 2 Macroglobulin anticorps (ABIN5541044)

Antigène: alpha 2 Macroglobulin (A2M) (alpha-2-Macroglobulin (A2M))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp alpha 2 Macroglobulin est non-conjugé

Application: Enzyme Immunoassay (EIA), Radioimmunoassay (RIA)

Clone: 2N1-10

Détail du produit anti-alpha 2 Macroglobulin anticorps

Specificité: This antibody recognises alpha 2-macroglobulin, a tetrameric glycoprotein of 720 kDa which functions as a proteinase inhibitor. Species: Human.

Purification: DEAE-chromatography

Immunogène: Purified alpha-2 macroglobulin from human plasma.

Isotype: IgG1

Information d'application

Indications d'application: ELISA. Radioimmunoassays

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS containing 0.09 % Sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Date de péremption: 12 months

Détails sur alpha 2 Macroglobulin

Antigène: alpha 2 Macroglobulin (A2M) (alpha-2-Macroglobulin (A2M))

Autre désignation: alpha-2-macroglobulin,a2m

Sujet: Alpha 2 macroglobulin is a serum protein which is mainly synthesised in the liver. It functions as a broad range irreversible proteinase inhibitor that forms a trap around most proteases. Alpha 2 macroglobulin is a tetrameric molecule, and with a molecular weight of 720 kDa, it so large a molecule that it tends to remain intravascular. Following conformational change the proteinase is deposited within a central cavity where it is still active but prevented from further contact with its substrate. Removal of the complex is mediated by the generation of recognition sites which react with receptors on a variety of cells including macrophages and liver cells. Alpha 2 macroglobulin is localized on the surface of peripheral blood lymphocytes.

UniProt: P01023

Pathways: Lipid Metabolism